VANISH
Vasopressin versus Norepinephrine in Septic Shock
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 409 patients with septic shock, early vasopressin (± hydrocortisone) did not increase kidney-failure-free days versus norepinephrine, but reduced RRT use.
N
409
Disegno
Factorial 2×2 RCT
Esito
Kidney-failure-free days at 28 days
Rilevanza
3
RisultatoNo difference in primary endpoint. RRT 25.4% vs 35.3% (Δ −9.9%).
Gordon AC, et al. JAMA. 2016;316(5):509-518. 10.1001/jama.2016.10485
Discussione e critica
Norepinephrine stays first-line; vasopressin's renal signal is hypothesis-generating.