Uranga
Short vs Standard Antibiotic Duration in Hospitalised CAP
Paciente / Población Intervención / Exposición Comparación Desenlace
In 312 hospitalised adults with community-acquired pneumonia, antibiotics for ≥5 days guided by clinical stability was non-inferior to physician-directed duration (≥10 days) for 30-day clinical success.
N
312
Diseño
Multicenter, noninferiority open-label RCT
Desenlace
Clinical success at days 10 and 30
Relevancia
3
ResultadoITT clinical success day 10 48.6% (control) vs 56.3% (short, P=.18); day 30 88.6% vs 91.9% (P=.33); short duration noninferior.
Uranga A, et al. JAMA Intern Med. 2016;176(9):1257-1265. 10.1001/jamainternmed.2016.3633
Discusión y crítica
Supports a 5-day antibiotic course in clinically stable, afebrile hospitalised CAP — adopted by ATS/IDSA 2019 guidance.