TRUST

Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism

Paciente / Población Intervención / Exposición Comparación Desenlace

In 737 adults ≥65 yr with persistent subclinical hypothyroidism, titrated levothyroxine did not improve hypothyroid symptoms or tiredness compared with placebo.

737

Diseño

Double-blind RCT, 1 yr

Desenlace

Hypothyroid-symptom and tiredness scores (ThyPRO)

Relevancia

ResultadoNo significant difference in symptoms, tiredness or quality of life. TSH normalised in the levothyroxine arm.

Stott DJ, et al. N Engl J Med. 2017;376(26):2534-2544. 10.1056/NEJMoa1603825

Discusión y crítica

Reframed mild SCH in older adults as a laboratory abnormality, not a treatment indication — endorsed by ATA/ETA guidance.