TRUST
Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 737 adults ≥65 yr with persistent subclinical hypothyroidism, titrated levothyroxine did not improve hypothyroid symptoms or tiredness compared with placebo.
N
737
Design
Double-blind RCT, 1 yr
Endpunkt
Hypothyroid-symptom and tiredness scores (ThyPRO)
Relevanz
2
ErgebnisNo significant difference in symptoms, tiredness or quality of life. TSH normalised in the levothyroxine arm.
Stott DJ, et al. N Engl J Med. 2017;376(26):2534-2544. 10.1056/NEJMoa1603825
Diskussion & Kritik
Reframed mild SCH in older adults as a laboratory abnormality, not a treatment indication — endorsed by ATA/ETA guidance.