THINKER
Transplanting Hepatitis C Kidneys into Negative Kidney Recipients
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 20 HCV-negative recipients of hepatitis-C-viraemic donor kidneys, antiviral therapy achieved a sustained virologic response in every patient.
N
10
Schéma
Open-label single-centre pilot
Critère
Sustained virologic response at 12 weeks (SVR12)
Pertinence
3
RésultatSVR12 100% (20/20); median 6-month creatinine 1.1 mg/dL.
Goldberg DS, et al. N Engl J Med. 2017;376(24):2394-2395. 10.1056/NEJMc1705221
Discussion et critique
Unlocked a previously discarded donor pool; now standard practice in many US centres.