TARGET-CTCA
Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography (TARGET-CTCA)
Patient / Population Intervention / Exposure Comparison Outcome
In 3,170 patients with suspected ACS, infarction ruled out and an intermediate troponin, outpatient CT coronary angiography was compared with standard care on myocardial infarction or cardiac death.
N
3,170
Design
Multicentre (14 UK hospitals), prospective, randomised, open-label, blinded-endpoint (PROBE), parallel-group, event-driven superiority trial; 1:1 allocation to outpatient CTCA plus standard care or standard care alone; minimum 24 months and median 36 months follow-up; powered on 97 primary-outcome events in the standard-care arm
Endpoint
Composite of myocardial infarction or cardiac death (time to first event)