TADS

Treatment for Adolescents with Depression Study

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 439 adolescents with major depression, fluoxetine + CBT produced the highest 12-week response compared with fluoxetine, CBT or placebo monotherapy.

439

Disegno

4-arm RCT, USA

Esito

CGI-improvement response at 12 weeks

Rilevanza

RisultatoCombination 71%, fluoxetine 61%, CBT 43%, placebo 35%. Suicidal events more frequent on fluoxetine alone.

TADS Team. JAMA. 2004;292(7):807-820. 10.1001/jama.292.7.807

Discussione e critica

Established combination as first-line for moderate-to-severe adolescent depression and flagged the SSRI suicidality signal.