SYGMA 1
Symbicort Given As Needed in Mild Asthma 1
Doente / População Intervenção / Exposição Comparação Desfecho
In 3,849 patients with mild asthma, PRN budesonide-formoterol reduced severe exacerbations compared with PRN terbutaline.
N
3849
Desenho
Multicentre RCT
Desfecho
Well-controlled asthma weeks
Relevância
1
ResultadoWell-controlled asthma weeks 34.4% vs 31.1% (OR 1.14, 95% CI 1.00–1.30, p=0.046); severe exacerbation rate reduced 64% vs as-needed SABA (RR 0.36, 95% CI 0.27–0.49).
O'Byrne PM, et al. N Engl J Med. 2018;378(20):1865-1876. 10.1056/NEJMoa1715274
Discussão e crítica
Foundational evidence for GINA's recommendation against SABA-only therapy; PRN ICS-formoterol is the new standard for mild asthma.