SWITCH SWEDEHEART
Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome — a Stepped Wedge Cluster Randomized Evaluation in the SWEDEHEART-registry (SWITCH SWEDEHEART)
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 17,095 patients with an acute coronary syndrome, prasugrel as the default P2Y12 inhibitor was compared with ticagrelor on death, myocardial infarction or stroke at 1 year.
N
17 095
Schéma
Registry-based (SWEDEHEART), prospective, multicentre, open-label, stepped-wedge cluster-randomised trial; Swedish administrative regions form the clusters; all clusters start with ticagrelor as the default P2Y12 inhibitor and the order in which clusters switch to prasugrel as default is randomly assigned, one cluster switching every 9 months; outcomes captured through national registries with 1-year follow-up
Critère
Cumulative 1-year risk of the composite of death, myocardial infarction or stroke