SUP-ICU
Stress Ulcer Prophylaxis in the ICU
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 3,298 ICU patients at risk of GI bleeding, pantoprazole 40 mg/day did not change 90-day mortality versus placebo, but reduced clinically important GI bleeding.
N
3 298
Schéma
Multicentre RCT
Critère
90-day all-cause mortality
Pertinence
2
Résultat31.1% vs 30.4% (RR 1.02); clinically important GI bleeding 2.5% vs 4.2%.
Krag M, et al. N Engl J Med. 2018;379(23):2199-2208. 10.1056/NEJMoa1714919
Discussion et critique
Confirmed the bleeding-prevention benefit without infectious harm; foundation for modern PPI prophylaxis.