STRESS-L
Studying the Treatment Effects of Landiolol in Septic Shock
Doente / População Intervenção / Exposição Comparação Desfecho
In 126 patients with tachycardic septic shock, landiolol added to standard care did not change SOFA at 14 days versus standard care alone, with a numerical mortality-harm signal.
N
126
Desenho
Multicentre RCT, stopped early
Desfecho
Mean SOFA at 14 days
Relevância
3
Resultado8.8 vs 8.1 (NS). 28-d mortality 37.1% vs 25.4% (Δ +11.7%; 95% CI −4.4 to 27.8; p=0.16).
Whitehouse T, et al. JAMA. 2023;330(17):1641-1652. 10.1001/jama.2023.20134
Discussão e crítica
Routine β-blockade in septic shock is not supported and may harm; reserve for selected cardiac indications.