SPARTACUS
CT-Guided vs Adrenal-Vein-Sampling-Guided Treatment in Primary Aldosteronism
Patient / Population Intervention / Exposure Comparison Outcome
In 200 patients with primary aldosteronism, CT-based subtyping did not differ from adrenal-vein-sampling-based subtyping for antihypertensive intensity at 1 year.
N
200
Design
RCT, 12 mo
Endpoint
Intensity of antihypertensive therapy
Relevance
3
ResultNo significant differences in BP control, antihypertensive intensity or quality of life.
Dekkers T, et al. Lancet Diabetes Endocrinol. 2016;4(9):739-746. 10.1016/S2213-8587(16)30100-0
Discussion & critique
Power and selection criteria are heavily debated; the Endocrine Society still favours AVS, but in clear unilateral adenoma in younger patients CT alone is acceptable in many European centres.