Skapinakis NMA
Network Meta-Analysis of OCD Treatments
Paziente / Popolazione Intervento / Esposizione Confronto Esito
Across adults and children with OCD, psychological therapies (chiefly EX/RP) produced larger symptom reduction than each SSRI compared individually.
N
6652
Disegno
Network meta-analysis
Esito
Symptom severity (Y-BOCS)
Rilevanza
3
RisultatoIn children CBT > all SSRIs and most combinations; in adults psychotherapy ≥ pharmacotherapy.
Skapinakis P, et al. Lancet Psychiatry. 2016;3(8):730-739. 10.1016/S2215-0366(16)30069-4
Discussione e critica
Network synthesis confirms EX/RP-first ordering, especially in paediatric OCD.