Skapinakis NMA
Network Meta-Analysis of OCD Treatments
Patient / Population Intervention / Exposure Comparison Outcome
Across adults and children with OCD, psychological therapies (chiefly EX/RP) produced larger symptom reduction than each SSRI compared individually.
N
6,652
Design
Network meta-analysis
Endpoint
Symptom severity (Y-BOCS)
Relevance
3
ResultIn children CBT > all SSRIs and most combinations; in adults psychotherapy ≥ pharmacotherapy.
Skapinakis P, et al. Lancet Psychiatry. 2016;3(8):730-739. 10.1016/S2215-0366(16)30069-4
Discussion & critique
Network synthesis confirms EX/RP-first ordering, especially in paediatric OCD.