SINGLE-AF
The Efficacy and Safety of Non-vitamin K Antagonist Oral Anticoagulants for Intermediate Stroke Risk in Patients With Atrial Fibrillation
Patient / Population Intervention / Exposure Comparison Outcome
In 1,803 patients with atrial fibrillation at intermediate stroke risk, a direct oral anticoagulant was compared with no anticoagulation on the net composite of stroke, embolism, major bleeding and death at 2 years.
N
1,803
Design
Investigator-initiated, multicentre, open-label, superiority RCT with blinded outcome adjudication (PROBE), 1:1, permuted blocks stratified by centre, 24-month follow-up, South Korea
Endpoint
Composite of stroke, systemic embolism, ISTH major bleeding and cardiovascular death at 2 years