Scott CBT
Pragmatic CBT Trial in Bipolar Disorder
Patient / Population Intervention / Exposure Comparison Outcome
In 253 bipolar I/II patients in routine care, 22 sessions of cognitive therapy + TAU did not reduce recurrence overall compared with treatment as usual, but helped patients with fewer prior episodes.
N
253
Design
Pragmatic multicentre RCT, UK
Endpoint
Time to recurrence
Relevance
2
ResultNo overall difference; interaction (p=0.04): CBT helped only patients with <12 prior episodes.
Scott J, et al. Br J Psychiatry. 2006;188:313-320. 10.1192/bjp.188.4.313
Discussion & critique
Cooled enthusiasm; psychosocial therapy in bipolar is most useful early, before episodes accumulate.