SAVE
Sleep Apnea Cardiovascular Endpoints Trial
Doente / População Intervenção / Exposição Comparação Desfecho
In 2,717 adults with moderate-to-severe OSA and established CVD, CPAP plus usual care did not reduce major cardiovascular events compared with usual care alone.
N
2717
Desenho
Multicentre RCT
Desfecho
Composite of CV death, MI, stroke, hospitalisation for HF/UA/TIA
Relevância
2
ResultadoHR 1.10 (95% CI 0.91–1.32; p=0.34). CPAP adherence only 3.3 h/night. QoL, sleepiness and depression improved.
McEvoy RD, et al. N Engl J Med. 2016;375(10):919-931. 10.1056/NEJMoa1606599
Discussão e crítica
CPAP indication remains symptom-driven; do not start CPAP solely for CV risk reduction. Low adherence may limit external validity.