REVISE
Re-Evaluating the Inhibition of Stress Erosions
Doente / População Intervenção / Exposição Comparação Desfecho
In 4,821 invasively ventilated ICU patients, pantoprazole reduced clinically important upper GI bleeding versus placebo, without an infectious harm signal.
N
4821
Desenho
Multicentre RCT, REVISE
Desfecho
Clinically important upper GI bleeding
Relevância
2
Resultado1.0% vs 3.5% (HR 0.30; 95% CI 0.19–0.47). 90-d mortality 29.1% vs 30.9% (HR 0.94; NS).
Cook D, et al. N Engl J Med. 2024;391(1):9-20. 10.1056/NEJMoa2404245
Discussão e crítica
Confirms SUP-ICU; PPI prophylaxis recommended in invasively ventilated ICU patients.