REVISE

Re-Evaluating the Inhibition of Stress Erosions

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 4,821 invasively ventilated ICU patients, pantoprazole reduced clinically important upper GI bleeding versus placebo, without an infectious harm signal.

4 821

Schéma

Multicentre RCT, REVISE

Critère

Clinically important upper GI bleeding

Pertinence

Résultat1.0% vs 3.5% (HR 0.30; 95% CI 0.19–0.47). 90-d mortality 29.1% vs 30.9% (HR 0.94; NS).

Cook D, et al. N Engl J Med. 2024;391(1):9-20. 10.1056/NEJMoa2404245

Discussion et critique

Confirms SUP-ICU; PPI prophylaxis recommended in invasively ventilated ICU patients.