REDUCE
Reduction in the Use of Corticosteroids in Exacerbated COPD
Doente / População Intervenção / Exposição Comparação Desfecho
In 314 patients with a COPD exacerbation, 5 days of 40 mg prednisone was non-inferior for re-exacerbation at 180 days compared with 14 days of treatment.
N
314
Desenho
Multicentre RCT, Switzerland
Desfecho
Re-exacerbation within 180 days
Relevância
2
Resultado35.9% vs 36.8% (HR 0.95); non-inferiority margin met.
Leuppi JD, et al. JAMA. 2013;309(21):2223-2231. 10.1001/jama.2013.5023
Discussão e crítica
Established 5-day prednisone as the standard burst for COPD exacerbations.