REDUCE
Reduction in the Use of Corticosteroids in Exacerbated COPD
Patient / Population Intervention / Exposure Comparison Outcome
In 314 patients with a COPD exacerbation, 5 days of 40 mg prednisone was non-inferior for re-exacerbation at 180 days compared with 14 days of treatment.
N
314
Design
Multicentre RCT, Switzerland
Endpoint
Re-exacerbation within 180 days
Relevance
2
Result35.9% vs 36.8% (HR 0.95); non-inferiority margin met.
Leuppi JD, et al. JAMA. 2013;309(21):2223-2231. 10.1001/jama.2013.5023
Discussion & critique
Established 5-day prednisone as the standard burst for COPD exacerbations.