RECOVERY-RS
Respiratory Strategies in COVID-19
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,273 patients with COVID-19 acute hypoxaemic failure, CPAP reduced intubation or death versus conventional oxygen, while HFNO did not.
N
1.273
Design
Multicentre adaptive RCT, UK
Endpunkt
Composite of intubation or 30-day mortality
Relevanz
3
ErgebnisCPAP 36.3% vs O₂ 44.4% (p=0.03); HFNO no benefit.
Perkins GD, et al. JAMA. 2022;327(6):546-558. 10.1001/jama.2022.0028
Diskussion & Kritik
CPAP became standard for COVID-19 hypoxaemia; the HFNO null is partly explained by crossover.