RACE II
Rate Control Efficacy in Permanent Atrial Fibrillation: Lenient Versus Strict Rate Control II
Paciente / Población Intervención / Exposición Comparación Desenlace
In 614 patients with permanent atrial fibrillation, lenient rate control (resting heart rate <110 bpm) was non-inferior for a composite of cardiovascular events compared with strict rate control.
N
614
Diseño
Open-label non-inferiority RCT
Desenlace
Composite of CV death, HF hospitalisation, stroke, systemic embolism, bleeding, and life-threatening arrhythmic events
Relevancia
2
Resultado3-year cumulative incidence 12.9% (lenient) vs 14.9% (strict); difference -2.0 points (90% CI -7.6 to 3.5), within the 10-point non-inferiority margin (P<0.001 for non-inferiority).
Van Gelder IC, et al. N Engl J Med. 2010;362(15):1363-1373. 10.1056/NEJMoa1001337
Discusión y crítica
Event rates lower than expected and patients relatively young with preserved function, limiting generalisability. Established lenient rate control (<110 bpm) as an acceptable, simpler strategy in permanent AF.