ProMISe

Protocolised Management in Sepsis

Paciente / Población Intervención / Exposición Comparación Desenlace

In 1,260 UK patients with early septic shock, EGDT did not reduce 90-day all-cause mortality compared with usual care, and increased ICU length of stay.

1260

Diseño

Multicentre RCT, UK

Desenlace

90-day all-cause mortality

Relevancia

Resultado29.5% vs 29.2% (RR 1.01; p=0.90). EGDT increased ICU LOS and cost.

Mouncey PR, et al. N Engl J Med. 2015;372(14):1301-1311. 10.1056/NEJMoa1500896

Discusión y crítica

Sealed the obituary of bundled EGDT; early antibiotics and basic fluid/vasopressor care are what matter.