ProCESS
Protocolized Care for Early Septic Shock
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,341 patients with early septic shock, protocol-based EGDT or protocol-based standard care did not reduce 60-day in-hospital mortality compared with usual care.
N
1.341
Design
Multicentre 3-arm RCT, USA
Endpunkt
60-day in-hospital mortality
Relevanz
1
ErgebnisEGDT 21.0% vs protocol-standard 18.2% vs usual care 18.9% (p=0.83).
Yealy DM, et al. N Engl J Med. 2014;370(18):1683-1693. 10.1056/NEJMoa1401602
Diskussion & Kritik
Coupled with ARISE and ProMISe, ended mandatory CVP/ScvO₂ targets in septic shock; Surviving Sepsis 2016/2021 dropped them.