PRESC1SE-MI
PRospective Evaluation of the European Society of Cardiology 0/1-hour Algorithm's Safety and Efficacy for Triage of Patients With Suspected Myocardial Infarction (PRESC1SE-MI)
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 64,374 emergency patients with suspected myocardial infarction, the ESC 0/1-hour troponin algorithm was compared with the 0/3-hour algorithm on death or type 1 myocardial infarction at 30 days, and length of stay.
N
64.374
Disegno
International, investigator-initiated, multicentre, pragmatic, stepped-wedge cluster-randomised, open-label trial; emergency departments still using the ESC 0/3-hour algorithm as standard of care are randomised to early or late implementation of the ESC 0/1-hour algorithm, with a validation phase on the 0/3-hour algorithm beforehand; consecutive patients enrolled; 30-day follow-up; designed for non-inferiority on safety and superiority on efficacy with at least 90% power
Esito
Co-primary — (1) composite of all-cause death or type 1 myocardial infarction within 30 days of the index presentation (safety); (2) length of stay in the emergency department, from presentation to discharge or transfer (efficacy)