PREOXI
Noninvasive Ventilation for Preoxygenation during Emergency Intubation
Patient / Population Intervention / Exposure Comparison Outcome
In 1,301 critically ill adults, NIV preoxygenation halved hypoxaemia during intubation versus oxygen face-mask.
N
1,301
Design
Multicentre RCT, US EDs/ICUs
Endpoint
Hypoxaemia (SpO₂ < 85%) during intubation
Relevance
2
Result9.1% vs 18.5% (Δ −9.4 pp; p<0.001). SpO₂ < 70%: 2.4% vs 5.7%.
Gibbs KW, et al. N Engl J Med. 2024;390(23):2165-2177. 10.1056/NEJMoa2313680
Discussion & critique
Shifts emergency-department preoxygenation toward NIV in hypoxaemic, obese or critically ill patients.