PPCOS-II
Pregnancy in Polycystic Ovary Syndrome II
Paciente / Población Intervención / Exposición Comparación Desenlace
In 750 women with polycystic ovary syndrome and infertility, letrozole improved the cumulative live-birth rate compared with clomiphene.
N
750
Diseño
Double-blind RCT, up to 5 treatment cycles
Desenlace
Cumulative live-birth rate
Relevancia
2
Resultado27.5% vs 19.1%; RR 1.44, 95% CI 1.10-1.87 (p=0.007).
Legro RS, et al. N Engl J Med. 2014;371(2):119-129. 10.1056/NEJMoa1313517
Discusión y crítica
Letrozole became first-line for ovulation induction in PCOS — still off-label in Germany but endorsed by reproductive-endocrinology guidance.