POTS
Pediatric OCD Treatment Study
Patient / Population Intervention / Exposure Comparison Outcome
In 112 children and adolescents with OCD, CBT alone or combined with sertraline produced higher 12-week remission than sertraline or placebo alone.
N
112
Design
4-arm RCT, USA
Endpoint
CY-BOCS ≤10 remission at 12 weeks
Relevance
2
ResultCombination 53.6%, CBT 39.3%, sertraline 21.4%, placebo 3.6%.
POTS Team. JAMA. 2004;292(16):1969-1976. 10.1001/jama.292.16.1969
Discussion & critique
Made CBT first-line in paediatric OCD, with combination reserved for more severe cases.