PEPTIC
Proton Pump Inhibitor versus Histamine-2 Receptor Blocker for Ulcer Prophylaxis
Patient / Population Intervention / Exposure Comparison Outcome
In 26,982 ventilated ICU patients, PPI prophylaxis did not change 90-day in-hospital mortality versus H₂-receptor antagonists.
N
26,982
Design
Cluster-randomised crossover trial, 50 ICUs across Australia, New Zealand, Canada, England, Ireland
Endpoint
90-day in-hospital mortality
Relevance
3
Result18.3% vs 17.5% (RR 1.05). No difference in infectious complications.
PEPTIC Investigators. JAMA. 2020;323(7):616-626. 10.1001/jama.2019.22190
Discussion & critique
Either agent acceptable; modern preference is PPI based on REVISE.