OSCILLATE
High-Frequency Oscillatory Ventilation in Early ARDS
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 548 patients with moderate–severe ARDS, high-frequency oscillatory ventilation increased in-hospital mortality compared with low-tidal-volume ventilation.
N
548
Disegno
Multicentre RCT, stopped early for harm
Esito
In-hospital mortality
Rilevanza
2
Risultato47% vs 35%.
Ferguson ND, et al. N Engl J Med. 2013;368(9):795-805. 10.1056/NEJMoa1215554
Discussione e critica
Stopped HFOV as a routine rescue; OSCAR confirmed neutrality.