NELSON
Dutch-Belgian Lung Cancer Screening Trial
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 15,789 high-risk men (and a small subgroup of women), volume-based LDCT at baseline, 1, 3 and 5.5 years reduced lung-cancer mortality at 10 years compared with no screening.
N
15.789
Disegno
Multicentre RCT, Netherlands/Belgium
Esito
Lung-cancer mortality at 10 years
Rilevanza
2
RisultatoMen RR 0.76 (95% CI 0.61–0.94); women RR 0.67 (95% CI 0.38–1.14).
de Koning HJ, et al. N Engl J Med. 2020;382(6):503-513. 10.1056/NEJMoa1911793
Discussione e critica
Confirmed NLST in a European population versus no-screening; volume-based criteria reduced false positives.