Fracture Prevention Trial
Effect of Parathyroid Hormone (1-34) on Fractures
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 1,637 postmenopausal women with prior vertebral fractures, teriparatide 20 or 40 µg daily reduced new vertebral and non-vertebral fractures compared with placebo.
N
1.637
Design
Double-blind RCT, median 21 mo (stopped early for rat osteosarcoma signal)
Endpunkt
New vertebral fracture
Relevanz
2
ErgebnisVertebral fracture 5 % vs 14 %; RR 0.35 (20 µg) — −65 %. Non-vertebral fragility −53 %.
Neer RM, et al. N Engl J Med. 2001;344(19):1434-1441. 10.1056/NEJM200105103441904
Diskussion & Kritik
First anabolic agent for osteoporosis — reserved for very high fracture risk and mandates sequential antiresorptive therapy thereafter.