Morrison ACTION
CBT for Patients Refusing Antipsychotics
Patient / Population Intervention / Exposure Comparison Outcome
In 74 patients with schizophrenia who declined antipsychotics, CBT alone reduced PANSS total compared with treatment as usual.
N
74
Design
Single-blind RCT, UK
Endpoint
PANSS total at 18 months
Relevance
3
ResultPANSS difference −6.52 (ES −0.46); safe adverse-event profile.
Morrison AP, et al. Lancet. 2014;383(9926):1395-1403. 10.1016/S0140-6736(13)62246-1
Discussion & critique
Made an evidence-based case for offering CBT as monotherapy when patients refuse antipsychotics.