MINT
Myocardial Ischemia and Transfusion
Patient / Population Intervention / Exposure Comparison Outcome
In 3,504 patients with acute myocardial infarction and Hb <10 g/dL, a restrictive transfusion strategy (Hb <8) did not change 30-day death or recurrent MI versus a liberal strategy (Hb <10), with a trend toward harm.
N
3,504
Design
Multicentre RCT, USA
Endpoint
30-day death or recurrent MI
Relevance
2
Result16.9% vs 14.5% (RR 1.15; 95% CI 0.99–1.34; p=0.07). 6-mo data favour liberal.
Carson JL, et al. N Engl J Med. 2023;389(26):2446-2456. 10.1056/NEJMoa2307983
Discussion & critique
Carve-out from the Hb-7 default: in acute MI, target ~9–10 g/dL.