MERINO
Piperacillin-Tazobactam vs Meropenem for ESBL Bacteraemia
Doente / População Intervenção / Exposição Comparação Desfecho
In 391 patients with ceftriaxone-non-susceptible E. coli or K. pneumoniae bacteraemia, piperacillin-tazobactam increased 30-day mortality compared with meropenem.
N
391
Desenho
Open-label non-inferiority RCT
Desfecho
30-day all-cause mortality
Relevância
2
Resultado30-day mortality 12.3% (23/187) vs 3.7% (7/191); risk difference 8.6% (1-sided 97.5% CI −∞ to 14.5%), P=.90 for noninferiority — noninferiority not met.
Harris PNA, et al. JAMA. 2018;320(10):984-994. 10.1001/jama.2018.12163
Discussão e crítica
Definitive evidence to use carbapenems for ESBL bloodstream and intra-abdominal infection — piperacillin-tazobactam is not equivalent.