MELODY

Nirsevimab for Prevention of RSV in Healthy Infants

Paciente / Población Intervención / Exposición Comparación Desenlace

In 1,490 healthy late-preterm and term infants, a single intramuscular dose of nirsevimab reduced medically attended RSV-associated lower-respiratory-tract infection compared with placebo.

1490

Diseño

Double-blind RCT

Desenlace

Medically attended RSV-LRTI

Relevancia

Resultado1.2 % vs 5.0 %; efficacy 74.5 %.

Hammitt LL, et al. N Engl J Med. 2022;386(9):837-846. 10.1056/NEJMoa2110275

Discusión y crítica

Established universal infant RSV monoclonal prophylaxis — now standard in many countries during the RSV season.