LOVIT
Lessening Organ Dysfunction with Vitamin C
Patient / Population Intervention / Exposure Comparison Outcome
In 872 ICU patients with sepsis on vasopressors, high-dose intravenous vitamin C increased the composite of death or persistent organ dysfunction at 28 days versus placebo.
N
872
Design
Multicentre RCT
Endpoint
Death or persistent organ dysfunction at 28 days
Relevance
1
Result44.5% vs 38.5% (RR 1.21; 95% CI 1.04–1.40) — signal of harm.
Lamontagne F, et al. N Engl J Med. 2022;386(25):2387-2398. 10.1056/NEJMoa2200644
Discussion & critique
Ended enthusiasm for the Marik vitamin C cocktail; avoid in sepsis.