Look AHEAD
Action for Health in Diabetes
Doente / População Intervenção / Exposição Comparação Desfecho
In 5,145 patients with T2DM and BMI ≥25, intensive lifestyle intervention did not reduce cardiovascular events compared with diabetes support and education.
N
5145
Desenho
RCT, stopped early for futility at 9.6 yr
Desfecho
CV death, non-fatal MI, non-fatal stroke or hospitalisation for angina
Relevância
2
ResultadoPrimary endpoint HR 0.95 (p=0.51). Weight loss 6.0 % vs 3.5 %; remission, sleep apnoea and mobility improved.
Look AHEAD Research Group. N Engl J Med. 2013;369(2):145-154. 10.1056/NEJMoa1212914
Discussão e crítica
Despite the null primary endpoint, demonstrated meaningful non-CV benefits — and set up the SELECT-era debate about which weight-loss approach delivers MACE reduction.