Look AHEAD
Action for Health in Diabetes
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 5,145 patients with T2DM and BMI ≥25, intensive lifestyle intervention did not reduce cardiovascular events compared with diabetes support and education.
N
5 145
Schéma
RCT, stopped early for futility at 9.6 yr
Critère
CV death, non-fatal MI, non-fatal stroke or hospitalisation for angina
Pertinence
2
RésultatPrimary endpoint HR 0.95 (p=0.51). Weight loss 6.0 % vs 3.5 %; remission, sleep apnoea and mobility improved.
Look AHEAD Research Group. N Engl J Med. 2013;369(2):145-154. 10.1056/NEJMoa1212914
Discussion et critique
Despite the null primary endpoint, demonstrated meaningful non-CV benefits — and set up the SELECT-era debate about which weight-loss approach delivers MACE reduction.