Lam CBT

Cognitive Therapy Adjunct in Bipolar Disorder

Patient / Population Intervention / Exposure Comparison Outcome

In 103 euthymic bipolar I patients, 14 sessions of cognitive therapy + treatment as usual reduced 12-month relapse compared with treatment as usual alone.

103

Design

RCT, UK

Endpoint

Bipolar relapse at 12 months

Relevance

ResultRelapse 44% (CBT) vs 75% (TAU); 30-month follow-up showed waning effect.

Lam DH, et al. Arch Gen Psychiatry. 2003;60(2):145-152. 10.1001/archpsyc.60.2.145

Discussion & critique

First clear demonstration of CBT relapse prevention in bipolar; effect attenuates and depends on early-course delivery.