INTERACT-3
Care Bundle for Acute Intracerebral Haemorrhage
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 7,036 patients with acute ICH across 121 hospitals, a bundle of BP, glucose, temperature and anticoagulation reversal improved functional outcome at 6 months versus usual care.
N
7 036
Schéma
Cluster-randomised stepped-wedge trial
Critère
mRS at 6 months
Pertinence
2
RésultatCommon OR for better outcome 0.86 (95% CI 0.76–0.97).
Ma L, et al. Lancet. 2023;402(10395):27-40. 10.1016/S0140-6736(23)00806-1
Discussion et critique
Largest ICH trial; supports a coordinated bundle rather than chasing single targets.