INTERACT-2
Intensive Blood-Pressure Reduction in Acute ICH
Patient / Population Intervention / Exposure Comparison Outcome
In 2,839 patients with acute intracerebral haemorrhage, intensive blood-pressure lowering (SBP <140) did not reduce 90-day death or major disability versus standard (<180), but improved ordinal mRS.
N
2,839
Design
Multicentre RCT
Endpoint
90-day death or major disability (mRS 3–6)
Relevance
1
Result52.0% vs 55.6% (OR 0.87; p=0.06). Ordinal mRS better with intensive (p=0.04).
Anderson CS, et al. N Engl J Med. 2013;368(25):2355-2365. 10.1056/NEJMoa1214609
Discussion & critique
Pushed acute ICH BP target toward 140 mm Hg.