ICAP
Investigation on Colchicine for Acute Pericarditis
Doente / População Intervenção / Exposição Comparação Desfecho
In 240 patients with a first episode of acute pericarditis, colchicine added to conventional anti-inflammatory therapy reduced incessant or recurrent pericarditis compared with placebo.
N
240
Desenho
Double-blind, placebo-controlled RCT
Desfecho
Incessant or recurrent pericarditis
Relevância
1
Resultado16.7 % vs 37.5 % (relative risk reduction 0.56; 95 % CI 0.30–0.72; NNT 4; p<0.001). Remission at 1 week 85.0 % vs 58.3 %. Adverse events comparable.
Imazio M, Brucato A, Cemin R, et al. N Engl J Med. 2013;369(16):1522-1528. 10.1056/NEJMoa1208536
Discussão e crítica
Modest in size, Italian centres only, and bacterial and neoplastic aetiologies were excluded, so the effect applies to idiopathic or viral pericarditis. It converted colchicine from a rescue drug into routine first-line adjunctive therapy from the first attack onwards.