HPTN 052
Antiretroviral Therapy to Prevent HIV Transmission in Serodiscordant Couples
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 1,763 HIV-serodiscordant couples, early antiretroviral therapy of the HIV-positive partner reduced linked HIV transmission compared with delayed ART.
N
1 763
Schéma
Open-label RCT
Critère
Linked HIV transmission
Pertinence
1
RésultatInterim: 96 % reduction in linked transmissions; final 93 % reduction overall and zero transmissions during virological suppression.
Cohen MS, et al. N Engl J Med. 2011;365(6):493-505; 2016;375(9):830-839. 10.1056/NEJMoa1105243
Discussion et critique
Foundational evidence for treatment as prevention — drove WHO's universal-treatment recommendation.