HF-ACTION
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 2,331 patients with heart failure and reduced ejection fraction, a supervised aerobic exercise-training programme did not significantly reduce all-cause mortality or hospitalisation compared with usual care.
N
2.331
Design
Randomised controlled trial, median follow-up 30 months
Endpunkt
All-cause mortality or all-cause hospitalisation
Relevanz
2
Ergebnis65 % vs 68 % (HR 0.93; 95 % CI 0.84–1.02; p=0.13); prespecified adjusted HR 0.89 (95 % CI 0.81–0.99; p=0.03). No excess of adverse events.
O'Connor CM, Whellan DJ, Lee KL, et al. JAMA. 2009;301(14):1439-1450. 10.1001/jama.2009.454
Diskussion & Kritik
The unadjusted primary endpoint was neutral and adherence fell steadily, so it arguably tested exercise prescription rather than exercise itself. It is the only adequately powered outcome trial of training in heart failure, established its safety, and underpins the class-I recommendation for exercise training.