HACA

Hypothermia after Cardiac Arrest

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 275 comatose survivors of out-of-hospital VF arrest, therapeutic hypothermia 32–34 °C for 24 hours improved favourable neurologic outcome at 6 months versus standard normothermia.

275

Disegno

Multicentre RCT, Europe

Esito

Favourable neurologic outcome (CPC 1–2) at 6 months

Rilevanza

Risultato55% vs 39% (RR 1.40; p=0.009). 6-mo mortality 41% vs 55%.

HACA Study Group. N Engl J Med. 2002;346(8):549-556. 10.1056/NEJMoa012689

Discussione e critica

With Bernard 2002, defined post-arrest hypothermia for two decades — later qualified by TTM and TTM2.