FLORALI
High-Flow Nasal Oxygen versus NIV in Acute Hypoxaemic Failure
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 310 patients with acute non-hypercapnic hypoxaemic respiratory failure, high-flow nasal oxygen improved 90-day mortality compared with standard oxygen or NIV.
N
310
Disegno
Multicentre RCT
Esito
Intubation rate at 28 days
Rilevanza
2
RisultatoIntubation similar overall; 90-d mortality HR 2.01 for standard O₂ vs HFNO (p=0.046) and 2.50 for NIV vs HFNO (p=0.006).
Frat JP, et al. N Engl J Med. 2015;372(23):2185-2196. 10.1056/NEJMoa1503326
Discussione e critica
HFNO is now first-line for acute hypoxaemic failure outside hypercapnia.