FLORALI
High-Flow Nasal Oxygen versus NIV in Acute Hypoxaemic Failure
Paciente / Población Intervención / Exposición Comparación Desenlace
In 310 patients with acute non-hypercapnic hypoxaemic respiratory failure, high-flow nasal oxygen improved 90-day mortality compared with standard oxygen or NIV.
N
310
Diseño
Multicentre RCT
Desenlace
Intubation rate at 28 days
Relevancia
2
ResultadoIntubation similar overall; 90-d mortality HR 2.01 for standard O₂ vs HFNO (p=0.046) and 2.50 for NIV vs HFNO (p=0.006).
Frat JP, et al. N Engl J Med. 2015;372(23):2185-2196. 10.1056/NEJMoa1503326
Discusión y crítica
HFNO is now first-line for acute hypoxaemic failure outside hypercapnia.