FIT (Vertebral Fracture Arm)
Fracture Intervention Trial — Vertebral Fracture Arm
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 2,027 postmenopausal women with ≥1 prevalent vertebral fracture, alendronate reduced new vertebral, clinical and hip fractures compared with placebo.
N
2027
Disegno
Double-blind RCT, 36 mo
Esito
New morphometric vertebral fracture
Rilevanza
1
RisultatoVertebral fracture RR 0.53; clinical vertebral RR 0.45; hip fracture RR 0.49 (p=0.047).
Black DM, et al. Lancet. 1996;348(9041):1535-1541. 10.1016/S0140-6736(96)07088-2
Discussione e critica
Established bisphosphonates as first-line antifracture therapy — still the foundation of modern osteoporosis treatment.